Pandemic Stress and Cyberbullying Among Adolescents During China's Outbreak of Omicron: Examining the Roles of Perceived Safety and Family Cohesion.

The COVID-19 pandemic posed risks to the psychosocial development of children and adolescents in the digital age. Under such a background, this study aims to examine the effects of pandemic stress on cyberbullying perpetration and victimization among Chinese adolescents, and to explore the mediator of perceived safety and the moderator of family cohesion underlying this association, during China's outbreak of Omicron. A sample of 822 adolescents was obtained from Taizhou in Zhejiang Province, China, based on a multistage cluster random sampling method. The results showed that pandemic stress was positively associated with cyberbullying perpetration and victimization. Moreover, pandemic stress negatively predicted perceived safety, which in turn, increased the probability of cyberbullying perpetration and victimization. Furthermore, family cohesion moderated the effects of pandemic stress on cyberbullying perpetration and victimization. This study contributes to practical implications for policy making and social work practices regarding how to protect adolescents from cyberbullying during the pandemic.

Exploring the associations between competence in dementia care and work attitudes among formal caregivers in nursing homes.

AIMS: Based on the two-factor model of caregiving appraisals, this study aims to (1) investigate the relationships between competence in dementia care and job satisfaction (work attitudes in positive aspect) and turnover intention (work attitudes in negative aspect) among formal caregivers in nursing homes, and (2) examine the mediating roles of positive aspects of caregiving (caregiving appraisals in positive aspect) and caregiving burden (caregiving appraisals in negative aspect) in the above associations. DESIGN: A cross-sectional design was used. Structural equation modelling was employed to test the proposed model. STROBE checklist guides the reporting of this study. METHODS: Using the multistage cluster sampling method, 407 formal caregivers were selected from 43 nursing homes across 7 districts/counties in China. RESULTS: The proposed model shows a good model fit. Competence in dementia care shows significant positive associations with increased job satisfaction and decreased turnover intention among formal caregivers in nursing homes. Caregiving burden and positive aspects of caregiving mediate the relationships between competence in dementia care and both job satisfaction and turnover intention. Furthermore, the relationship between positive aspects of caregiving and job satisfaction is stronger than that with turnover intention, but the relationship between caregiving burden and turnover intention is not stronger than that with job satisfaction. CONCLUSIONS: The results demonstrate that the two-factor model of caregiving appraisals effectively elucidates the associations and underlying mechanisms between competence in dementia care and formal caregivers' work attitudes. Specifically, two crucial conclusions are drawn: (1) competence in dementia care is associated with higher levels of job satisfaction and lower levels of turnover intention among formal caregivers in nursing homes; (2) caregiving burden and positive aspects of caregiving serve as parallel mediators in these associations. IMPLICATIONS FOR THE PROFESSION AND/OR PATIENT CARE: Policymakers and nursing homes managers should implement a series of measures aimed at formal caregivers in nursing home. Specifically, allocating more resources to enhance the competence in dementia care of formal caregivers is crucial, given its significant association with elevated job satisfaction and reduced turnover intention. Besides, positive and negative caregiving appraisals emerge as proximal factors influencing work attitudes of formal caregivers. Therefore, intervention projects focused on formal caregivers in nursing home should target enhancing positive experiences and alleviating caregiving burden. PATIENT OR PUBLIC CONTRIBUTION: No patient or public contribution.

The relationship between bullying victimization and problematic behaviors: A focus on the intrapersonal emotional competence and interpersonal social competence.

BACKGROUND: Evidence consistently demonstrated that bullying victimization was associated with problematic behaviors among adolescents. However, scant attention has been given to simultaneous comparisons of the impacts of two distinct forms of victimization, traditional bullying victimization and cyberbullying victimization. In addition, the mechanisms underlying the relationship between bullying victimization and problem behavior remain inadequately explored. OBJECTIVE: This study aimed to examine the correlation between bullying victimization and problematic behaviors, as well as the mediating roles of intrapersonal emotional competence and interpersonal social competence. PARTICIPANTS AND SETTING: A sample of 26,450 adolescents with a mean age of 15.44 (SD = 0.56) across nine countries was derived from the Study on Social and Emotional Skills (SSES). METHODS: Data analysis was conducted using structural equation modeling, comprising three key components: the measurement model, the structural model, and the bootstrapping analysis for mediating effects. RESULTS: Both traditional bullying and cyberbullying victimization exhibited positive correlations with problematic behaviors, with cyberbullying victimization demonstrating a stronger effect. The mediating effects of intrapersonal emotional competence and interpersonal social competence were observed in the correlation between bullying victimization and problematic behaviors. CONCLUSIONS: This study not only contributed to our comprehension of the underlying mechanisms connecting bullying victimization and adolescent problematic behaviors, but also holds significance for policy development and practice.

Factors mitigate the effect of widowhood's mental health impact: A longitudinal test from individual, familial, and social perspectives.

Although widowhood has been considered a significant risk factor for mental health, the duration of its effects and the potential mitigating factors involved in this relationship remain inadequately understood among Chinese older adults. This study investigates the longitudinal relationship between widowhood and depression and examines the interaction effects of health asymmetry, the number of children, and urban-rural differences from individual, familial, and social perspectives. A sample of 9,563 individuals for the four rounds period (from 2011 to 2018) is obtained from the China Health and Retirement Longitudinal Study. Results demonstrate that (a) the depression associated with widowhood is expected to revert to prewidowhood level after 3 years, (b) the relationship between widowhood and depression is stronger for older adults who are health pessimists compared to those who are health optimists, (c) the relationship between widowhood and depression is stronger for older adults with fewer children compared to those with more children, and (d) the relationship between widowhood and depression is stronger for older adults living in rural areas than those living in urban areas. These findings are essential for policymakers and practitioners working with widowed older adults. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

The Long Arm of Childhood Bullying Victimization: Associations with Social Isolation, Gender Differences and Depression in Later Life.

The association between childhood bullying victimization and depression has been well-explored among young adults, but little is known about whether this relationship persists into later life stages, specifically during middle-aged and older phases. Moreover, the intricate mechanisms underpinning this association and the potential existence of gender differences within this context remain inadequately elucidated. To address this gap in knowledge, this study aims to investigate the association between childhood bullying victimization and depression in later life, with a focus on exploring the mediating role of social isolation and the moderating roles of gender. A nationally representative sample of 5,070 individuals (mean age = 61.02, SD = 9.48; male = 55%) was drawn from the China Health and Retirement Longitudinal Study. By employing the bootstrapping analysis method, the mediating role of social isolation was examined, and the moderating role of gender was tested through the generation of interaction items. The results reveal a significant association between childhood bullying victimization and severe depression in later life. Additionally, social isolation plays a mediating role in this association between childhood bullying victimization and social isolation, and the association between social isolation and depression, as well as the relationship between social isolation and depression, are both moderated by gender, presenting stronger effects for female groups than for male groups. However, no moderating role of gender is found in terms of the direct association between childhood bullying victimization and depression. These findings highlight the fact that childhood bullying is not only a problem in the immediate term but also a concern that affects individuals across entire life course. This study has implications for healthcare in proactively investigating, diagnosing, and treating depression by inquiring about childhood bullying victimization experiences. Furthermore, intervention policies that aim to reduce social isolation may be particularly beneficial in mitigating the negative associations, especially for female individuals.

Community support, social isolation and older adults' life satisfaction: evidence from a national survey in China.

OBJECTIVES: Despite the recognized importance of community social service and community built facility for enhancing older adults' life satisfaction, the mechanisms underlying their relationship have not been thoroughly examined. This study aims to complement the existing knowledge by investigating the mediating role of social disconnectedness and loneliness in the association between community support and life satisfaction among older adults. METHODS: Using data from the 2018 China Longitudinal Aging Social Survey, the study analyzes responses from 9,874 Chinese older adults (mean age = 71.30 years, SD = 7.30). We conducted descriptive statistics and Pearson's correlation to explore the variables. This study also used Mplus 8.0 to conduct a path analysis model that evaluated both the direct and indirect effects of community social service and built facility on life satisfaction. Social disconnectedness and loneliness were included as mediating variables in this model. RESULTS: The present study results show that both community social service and community built facility are positively associated with life satisfaction among older adults, and community social service is more imporatant for enhancing the life satisfaction. In addition, these associations are mediated by social disconnectedness and loneliness. CONCLUSION: Our research suggests that strengthening community social service programs and improving the built environment can reduce social disconnectedness and loneliness among older adults, ultimately enhancing their life satisfaction. Specifically, policymakers can invest in targeted interventions to enhance social connectedness and reduce loneliness, with the goal of improving the overall well-being of older adults.

Multimode-Responsive Luminescence of Er3+ Single-Activated CaF2 Phosphor for Advanced Information Encryption.

The current optical anticounterfeit strategies that rely on multimode luminescence in response to the photon or thermal stimuli have significant importance in the field of anticounterfeiting and information encryption. However, the dependence on light and heat sources might limit their flexibility in practical applications. In this work, Er3+ single-doped CaF2 phosphors that show multistimuli-responsive luminescence have been successfully prepared. The as-obtained CaF2:Er3+ phosphor exhibits green photoluminescence (PL) and color-tunable up-conversation (UC) luminescence from red to green due to the cross-relaxation of Er3+ ions. Additionally, as-obtained CaF2:Er3+ phosphors also display green mechano-luminescence behavior, which is induced by the contact electrification between the CaF2 particles and PDMS polymers, enabling the phosphor to flexibly respond to mechanical stimuli. Moreover, feasible anticounterfeiting schemes with the capability of multistimuli-responsive and flexible decryption have been constructed, further expanding the application of optical materials in the field of advanced anticounterfeiting and information encryption.

Linking chronic diseases, cognitive impairment and depressive symptoms in Chinese older adults: A three-wave population-based longitudinal study.

OBJECTIVE: Despite previous studies illustrate that chronic diseases are risk factors for older adults' psychological health, little is known about its mediating mechanism. This study aims to examine the mediating effect of cognitive impairment. Also, a particular emphasis is placed on whether the Hukou system in China contributes to the adverse effect of chronic diseases on depressive symptoms. METHODS: Using the 2014, 2016 and 2018 rounds of the China Longitudinal Aging Social Survey (CLASS), this study estimates fixed-effect panel models for the effect of chronic diseases on depressive symptoms and the mediating effect of cognitive impairment. Meanwhile, the interaction effect of chronic diseases and hukou status on depressive symptoms is also examined. RESULTS: The significant relationship between chronic diseases and depressive symptoms is supported in Chinese older adults and this association is found to be mediated by cognitive impairment. Moreover, no urban-rural disparities exist in the effect of chronic diseases on depressive symptoms. LIMITATION: All of the measures in this study are relied on self-report, which may result in reporting biases. CONCLUSION: This study contributes to our understanding of the relationship between chronic diseases and depressive symptoms and extends the previous literature by considering the Hukou status, a highly distinctive Chinese variable. Practical implications for policy development and intervention design are also provided.

The impact of widowhood on mental health of older adults.

Widowhood is identified as a risk factor for older adults' mental health, however, the underlying mechanisms and protective factors in this association has not been fully revealed. In order to add to the current knowledge, this study investigates the mediating roles of economic, social and psychological resources and the moderating role of community support in the relationship between widowhood and mental health. A sample of 7913 Chinese older people (Mean age = 71.14, SD = 7.19) is obtained from the 2018 wave of China Longitudinal Aging Social Survey. Results indicates that widowhood is negatively associated with older adults' mental health. Economic, social and psychological resources partially mediate the above association. Furthermore, the effect of widowhood is weaker for older people with more rather than less community support. This study not only illuminates the potential mechanisms of how widowhood influence mental health theoretically, but also provides valuable implications.

Examining the mediator and moderator of the link between Migration-Related stress and depression amongst Chinese migrant children.

Migration-related stress is detrimental to children's mental health, yet little is known about the potential mechanisms behind this association. This study examines the mediating role of inflow city identity in the association between migration-related stress and depression and the moderating role of social participation amongst Chinese migrant children. A sample of 484 migrant children aged 8-17 years is randomly recruited through a cross-sectional survey in Kunming, China. Inflow city identity partially mediates the association between migration-related stress and migrant children's depression. Moreover, social participation moderates the above relationship. The direct and indirect effects are significant for migrant children with low social participation but insignificant for migrant children with high social participation. This study deepens the theoretical understanding of the underlying mechanism between migration stress and psychological distress and provides practical implications for preventing mental disorders in Chinese migrant children.

The Association of Body Mass Index With Mortality Among Pulmonary Hypertension Patients: A Systematic Review and Meta-Analysis of Cohort Studies.

Objective: To run a systematic review and meta-analysis of related studies on body mass index (BMI) and the risk of death among pulmonary hypertension (PH) patients, as well as, to shed light on the shape and strength of the dose-response association. Methods: Studies published up to Jun 2021 in scientific databases such as Scopus, and PubMed as well as Google Scholar were searched. Cohort studies that reported risk estimates for at least two categories of BMI or per certain increase in BMI in relation to mortality in PH patients were included. Summary relative risks were determined with random effects models. Non-linear relationship was discovered with dose-response analysis. Results: All in all, 15 cohort studies were selected. The number of participants was 127,215 out of which 73,999 were reported dead. The summary RR for mortality per a 5-unit increment in BMI was 0.83 (95% confidence interval 0.77-0.89; I2 = 75.6%, n = 9) among PH patients. There was a non-linear dose-response relation between BMI and mortality in PH patients (Pnon-linearity < 0.001), with the lowest risk being at BMI 32-38 kg/m2. Conclusion: Higher BMI is related to decreased risk of mortality among PH patients and the lowest point of the curve was seen at BMI 32-38.

Effects of Adverse Childhood Experiences on Late-life Mental Health: Potential Mechanisms Based on a Nationally Representative Survey in China.

Adverse childhood experiences (ACEs) are risk factors in the mental health of older adults; however, little is known about its underlying mechanisms. This study investigates the mediating role of physical and cognitive functions and the moderating role of number of children in the association between ACEs and mental health. A sample of 8,494 Chinese older adults are drawn from the 2018 China Longitudinal Aging Social Survey. Findings show that ACEs have negative effects on mental health of older adults. Physical and cognitive functions partially mediate the above relationship. Furthermore, the effect of ACEs on mental health is stronger for older adults with fewer rather than more children. This study advances extant knowledge by illuminating the possible mechanisms of how ACEs influence later-life mental health. Important policy and practical implications are provided.

Stressful Life Events and Life Satisfaction among Chinese Older Adults: The Role of Coping Styles.

This study aims to investigate the mediating effect of coping styles in the relationship between stressful life events and life satisfaction among Chinese older adults. To test the hypotheses, cross-sectional data (n = 8799) from the 2016 China Longitudinal Aging Social Survey (CLASS) were analyzed by Stata 15/SE in this study. Results indicated that stressful life events directly affected life satisfaction. Moreover, the association between stressful life events and life satisfaction was partially mediated by coping styles. This study had implications for the current body of knowledge and provided empirical evidence for social work practice and social policy.

Academic stress and depression of Chinese adolescents in junior high schools: Moderated mediation model of school burnout and self-esteem.

Background Despite previous research indicates that academic stress is a risk factor for students' mental health, the mediating and moderating mechanisms underlying this relationship are less known. This study tests the mediation effect of school burnout in the association between academic stress and adolescent depression, and whether this mediation is moderated by self-esteem. Methods A sample of 552 Chinese adolescents in junior high schools (mean age = 14.48 years, SD = 0.98) is obtained through multi-stage cluster random sampling. Mediation and moderation analyses are carried out in SPSS macro PROCESS. Results The association between academic stress and depression is found to be mediated by school burnout (b = 0.200, 95% CI [0.145, 0.263]). Moreover, the effect of school burnout on depression is moderated by self-esteem, with the effect being stronger for adolescents with low self-esteem (b = 0.377, p < 0.001) than for those with high self-esteem (b = 0.218, p < 0.001). Limitations The cross-sectional design of the study does not allow causal inferences. Conclusions These findings contribute to the understanding of how academic stress predicts adolescent depression, and provide practical implications for prevention and intervention programs to protect adolescents' mental health in the school setting.

Elder mistreatment and life satisfaction of older adults: mediating roles of emotional closeness with children and loneliness.

Elder mistreatment is a risk factor in the life satisfaction of older adults, yet understanding of its underlying mechanisms remains limited. This study investigates the mediating role of emotional closeness and loneliness in the association between elder mistreatment and life satisfaction. A sample of 8,717 Chinese older adults is obtained from the 2018 China Longitudinal Aging Social Survey. Results reveal that emotional mistreatment has a negative effect on the life satisfaction of older adults. Moreover, emotional mistreatment is associated with a low level of emotional closeness and a high degree of loneliness, which further decreases life satisfaction. However, emotional closeness with children did not significantly mediate the association between physical mistreatment and life satisfaction. This study advances the comprehension of the influencing path on how elder mistreatment affects the life satisfaction of older adults. Implications for policy and intervention programs are discussed.

Downregulation of Long Noncoding RNA LINC00261 Attenuates Myocardial Infarction through the miR-522-3p/Trinucleotide Repeat-Containing Gene 6a (TNRC6A) Axis.

BACKGROUND: Myocardial infarction (MI) is cardiac tissue necrosis caused by acute and persistent ischemic hypoxia of the coronary arteries. This study is aimed at investigating the expression of long noncoding RNA (lncRNA) LINC00261 in MI and its effect on myocardial cells. METHODS: qRT-PCR was performed to detect the expression levels of LINC00261, miR-522-3p, and TNRC6A in normal and MI cells. Western blotting analysis was performed to detect the expression of TNRC6A protein. Viability and apoptosis of myocardial cells after MI with the knockout of LINC00261 or TNRC6A were detected. The relationships among miR-522-3p, LINC00261, and TNRC6A in cardiomyocytes were evaluated using a double luciferase reporter gene assay. Hypoxic preconditioning in normal cells was used to construct a simulated MI environment to investigate the effect of LINC00261 on apoptosis of cardiac cells. RESULTS: LINC00261 and TNRC6A were upregulated, while miR-522-3p was downregulated in coronary heart disease tissues with MI. Knockout of LINC00261 can increase the viability of cardiomyocytes and inhibit cell apoptosis. LINC00261 targets miR-522-3p in cardiomyocytes. In addition, miR-522-3p targets TNRC6A in cardiomyocytes. TNRC6A regulates cell viability and apoptosis of cardiomyocytes after MI, and TNRC6A-induced MI can be reversed by overexpression of miR-522-3p. CONCLUSIONS: LINC00261 downregulated miR-522-3p in cardiomyocytes after MI by directly targeting miR-522-3p. TNRC6A is the direct target of miR-522-3p. Our results indicated that LINC00261 might serve as a therapeutic target for the treatment of MI.

Examining the link between economic strain and adolescent social behavior: Roles of social bonds and empathy.

INTRODUCTION: The detrimental effect of economic strain on adolescent behavioral development is well established, but the mechanisms explaining this relationship are less known. This study aims to explore the psychosocial factors operating as pathways connecting economic strain to adolescent antisocial and prosocial behaviors, and examine whether these effects differ by gender. METHODS: The sample includes 1280 adolescents from middle and high schools in Hebei province, China (Mean age = 15.68 years; 52.6% girls), collected by a multi-stage cluster random sampling. Multi-group structural equation modeling is adopted for data analysis. RESULTS: Social bonds partially mediate the relationship between economic strain and adolescent antisocial behavior, and empathy fully mediates the relationship between economic strain and prosocial behavior after controlling for gender, age, household registration, and subjective socioeconomic status. In terms of gender differences, boys display more antisocial behaviors and less prosocial behaviors compared with girls. Significant gender differences are also found in the effect of economic strain on adolescent social behavior. CONCLUSIONS: This study contributes to current knowledge by revealing the psychosocial mechanisms between economic strain and adolescent antisocial/prosocial behaviors. Findings highlight the gender differences in behavioral development among Chinese adolescents.

Dysregulated Serum MiRNA Profile and Promising Biomarkers in Dengue-infected Patients.

OBJECTIVES: Pathological biomarkers and mechanisms of dengue infection are poorly understood. We investigated a new serum biomarker using miRNAs and performed further correlation analysis in dengue-infected patients. METHODS: Expression levels of broad-spectrum miRNAs in serum samples from three patients with dengue virus type 1 (DENV-1) and three healthy volunteers were separately analyzed using miRNA PCR arrays. The expressions of the five selected miRNAs were verified by qRT-PCR in the sera of 40 DENV-1 patients and compared with those from 32 healthy controls. Receiver operating characteristic (ROC) curve and correlation analyses were performed to evaluate the potential of these miRNAs for the diagnosis of dengue infection. RESULTS: MiRNA PCR arrays revealed that 41 miRNAs were upregulated, whereas 12 miRNAs were down-regulated in the sera of DENV-1 patients compared with those in healthy controls. Among these miRNAs, qRT-PCR validation showed that serum hsa-miR-21-5p, hsa-miR-590-5p, hsa-miR-188-5p, and hsa-miR-152-3p were upregulated, whereas hsa-miR-146a-5p was down-regulated in dengue-infected patients compared with healthy controls. ROC curves showed serum hsa-miR-21-5p and hsa-miR-146a-5p could distinguish dengue-infected patients with preferable sensitivity and specificity. Correlation analysis indicated that expression levels of serum hsa-miR-21-5p and hsa-miR-146a-5p were negative and positively correlated with the number of white blood cells and neutrophils, respectively. Functional analysis of target proteins of these miRNAs in silico indicated their involvement in inflammation and cell proliferation. CONCLUSION: Dengue-infected patients have a broad "fingerprint" profile with dysregulated serum miRNAs. Among these miRNAs, serum hsa-miR-21-5p, hsa-miR-146a-5p, hsa-miR-590-5p, hsa-miR-188-5p, and hsa-miR-152-3p were identified as promising serum indicators for dengue infection.

[Alterations of peripheral blood endothelial progenitor cells from patients with ST elevation myocardial infarction after snake venom fibrinolytic enzyme therapy].

OBJECTIVE: To investigate the morphological and quantitative alterations of peripheral blood endothelial progenitor cells (EPCs) in patients with ST elevation myocardial infarction (STEMI) after snake venom fibrinolytic enzyme therapy. METHODS: Sixty patients with STEMI and 20 control patients free of STEMI were enrolled in this study. The mononuclear cells were isolated from the peripheral blood of the STEMI patients before and 3 and 7 days after fibrinolytic enzyme injection. The isolated cells were cultured in RPMI1640 medium supplemented with vascular endothelial growth factor 165 (VEGF165) and basic fibroblast growth factor (bFGF). The EPCs were characterized as adherent cells of positive for both DiL-acLDL and FITC-UEA-I by direct fluorescent staining. The cell morphology was observed and the number of the colony-forming units (CFU) was determined by phase-contrast microscope. RESULTS: The number of the EPCs increased obviously in patients with STEMI 3 days after fibrinolytic enzyme injection, and reduced 7 days after the injection but remained greater than that in the control group. The injection of fibrinolytic enzyme did not result obvious changes in the number of CFU in the patients with STEMI. CONCLUSION: Snake venom fibrinolytic enzyme injection can increase the peripheral blood EPCs in patients with STEMI.

[Relationship of angiotensin-converting enzyme 2 gene polymorphisms and vulnerability to coronary heart disease in patients with type 2 diabetes mellitus].

OBJECTIVE: To investigate the association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms and coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). METHODS: This study involved 121 patients with T2DM and 94 with diabetic macroangiopathy. The polymorphisms of G8790A in ACE2 gene was analyzed using PCR-restriction fragment length polymorphism analysis in these patients, and the clinical, biochemical and echocardiographic data were also analyzed. RESULTS: No obvious difference was found in the genotyping data between the two groups. Among the male patients with diabetic macroangiopathy, the interventricular septal end-diastolic thickness (IVSTd) were significantly greater in patients of GG genotypes of ACE2 gene G8790A than in those of AA genotypes (P<0.01), and the left ventricular mass (LVMI) and urine protein were also significantly higher in GG genotypes (P<0.05). No similar results were found the uncomplicated diabetic group or the female diabetic patients with CAD. CONCLUSION: The ACE2 gene G8790A polymorphism plays a role in the pathogenesis of CAD in patients with type 2 diabetes, suggesting that ACE2 genotyping is helpful to screen the susceptible patients.